Siderophores for molecular imaging applications

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73588571" target="_blank" >RIV/61989592:15110/17:73588571 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s40336-016-0211-x" target="_blank" >http://dx.doi.org/10.1007/s40336-016-0211-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s40336-016-0211-x" target="_blank" >10.1007/s40336-016-0211-x</a>

Result language

angličtina

Original language name

Siderophores for molecular imaging applications

Original language description

This review covers publications on siderophores applied for molecular imaging applications, mainly for radionuclide-based imaging. Siderophores are low molecular weight chelators produced by bacteria and fungi to scavenge essential iron. Research on these molecules has a continuing history over the past 50 years. Many biomedical applications have been developed, most prominently the use of the siderophore desferrioxamine (DFO) to tackle iron overload related diseases. Recent research described the upregulation of siderophore production and transport systems during infection. Replacing iron in siderophores by radionuclides, the most prominent Ga-68 for PET, opens approaches for targeted imaging of infection; the proof of principle has been reported for fungal infections using 68Ga-triacetylfusarinine C (TAFC). Additionally, fluorescent siderophores and therapeutic conjugates have been described and may be translated to optical imaging and theranostic applications. Siderophores have also been applied as bifunctional chelators, initially DFO as chelator for Ga-67 and more recently for Zr-89 where it has become the standard chelator in Immuno-PET. Improved DFO constructs and bifunctional chelators based on cyclic siderophores have recently been developed for Ga-68 and Zr-89 and show promising properties for radiopharmaceutical development in PET. A huge potential from basic biomedical research on siderophores still awaits to be utilized for clinical and translational imaging.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical and Translational Imaging

ISSN

2281-5872

e-ISSN

—

Volume of the periodical

5

Issue of the periodical within the volume

1

Country of publishing house

IT - ITALY

Number of pages

13

Pages from-to

15-27

UT code for WoS article

—

EID of the result in the Scopus database

2-s2.0-85010647557