Cardiac amyloidosis: from clinical suspicion to morphological diagnosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73586413" target="_blank" >RIV/61989592:15110/18:73586413 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.pathol.2017.10.012" target="_blank" >http://dx.doi.org/10.1016/j.pathol.2017.10.012</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pathol.2017.10.012" target="_blank" >10.1016/j.pathol.2017.10.012</a>

Result language

angličtina

Original language name

Cardiac amyloidosis: from clinical suspicion to morphological diagnosis

Original language description

Amyloidosis is a heterogeneous group of diseases characterised by extracellular accumulation of amyloid in various tissues and organs of the body, leading to alteration and destruction of tissues. Heart involvement is the most important prognostic factor in patients with systemic amyloidosis and the diagnosis and typing of amyloid must be made properly. The clinical picture shows congestive heart failure with predominant right-sided heart failure symptoms in fully developed disease, various types of arrhythmias and characteristic electrocardiography and echocardiography findings. Blood and urine monoclonal protein studies and cardiac biomarkers belong to the spectrum of standard laboratory examinations. Cardiac cardiomyopathy is connected with amyloid based on immunoglobulin light chains, serum amyloid A, transthyretin, atrial natriuretic factor or apolipoprotein A1. In the routine diagnostic algorithm, biopsy specimens are examined using special histological staining, immunohistochemistry and immunofluorescence; proteomic analysis is only performed in specialised centres.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PATHOLOGY

ISSN

0031-3025

e-ISSN

—

Volume of the periodical

50

Issue of the periodical within the volume

3

Country of publishing house

AU - AUSTRALIA

Number of pages

8

Pages from-to

261-268

UT code for WoS article

000428525100002

EID of the result in the Scopus database

2-s2.0-85044545386