Dapsone treatment is efficient against persistent cutaneous and gastrointestinal symptoms in children with Henoch-Schönlein purpura

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73587360" target="_blank" >RIV/61989592:15110/18:73587360 - isvavai.cz</a>
Result on the web
<a href="http://biomed.papers.upol.cz/artkey/bio-201802-0014_dapsone_treatment_is_efficient_against_persistent_cutaneous_and_gastrointestinal_symptoms_in_children_with_heno.php" target="_blank" >http://biomed.papers.upol.cz/artkey/bio-201802-0014_dapsone_treatment_is_efficient_against_persistent_cutaneous_and_gastrointestinal_symptoms_in_children_with_heno.php</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2017.044" target="_blank" >10.5507/bp.2017.044</a>

Result language
angličtina
Original language name
Dapsone treatment is efficient against persistent cutaneous and gastrointestinal symptoms in children with Henoch-Schönlein purpura
Original language description
Background. Henoch-Schönlein purpura (HSP) is a systemic disorder characterized by leukocytoclastic vasculitis involving the capillaries and by the deposition of IgA immune complexes. An association between HSP and atypical bacteria is uncommon in children. Methods and Results. Here we report three cases of children, aged 5, 4 and 16 years, who were diagnosed with HSP associated with Mycoplasma pneumoniae or Chlamydia pneumoniae infection. In all presented cases, persistent cutaneous manifestations and abdominal pain were resistant to antibiotics and corticosteroids, but resolved during 48 h after the introduction of dapsone. No adverse effects of treatment were observed. Conclusion. Dapsone, a sulphone with an anti-inflammatory activity, showed remarkable therapeutic efficacy against rash and gastrointestinal symptoms in children with HSP. Its administration should be considered particularly in persistent cutaneous form of HSP.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30219 - Gastroenterology and hepatology

Project
<a href="/en/project/LO1304" target="_blank" >LO1304: Support of suistainability of the Institute of Molecular and Translational Medicine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)