UVA-photoprotective potential of silymarin and silybin

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73588052" target="_blank" >RIV/61989592:15110/18:73588052 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/18:N0000034
Result on the web
<a href="https://link.springer.com/content/pdf/10.1007%2Fs00403-018-1828-6.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007%2Fs00403-018-1828-6.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00403-018-1828-6" target="_blank" >10.1007/s00403-018-1828-6</a>

Result language
angličtina
Original language name
UVA-photoprotective potential of silymarin and silybin
Original language description
Exposure to solar radiation is a major cause of environmental human skin damage. The main constituent of solar UV light is UVA radiation (320-400 nm); however, the need for protection against UVA has been marginalized for a long time. As a result, there is still a lack of useful agents for UVA protection. In this study, the effect of silymarin (SM) and its main constituent silybin (SB) pre-treatment on UVA-stimulated damage to primary human dermal fibroblasts were carried out. The cells were pre-treated for 1 h with SB or SM and then were exposed to UVA light, using a solar simulator. The effect of SB and SM on reactive oxygen species (ROS) and glutathione (GSH) level, caspase-3 activity, single-strand breaks (SSB) formation and protein level of matrix metalloproteinase-1 (MMP-1), heme oxygenase-1 (HO-1), and heat shock protein (HSP70) was evaluated. Treatment with both SM and SB resulted in a reduction in UVA-stimulated ROS generation and SSB production, as well as in the prevention of GSH depletion, a decrease in the activation of caspase-3 and protein level of MMP-1. They also moderately increased HO-1 level and reduced HSP70 level. Our data showed that both SM and SB are non-phototoxic and have UVA-photoprotective potential and could be useful agents for UV-protective dermatological preparations.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology

Project
<a href="/en/project/GA15-10897S" target="_blank" >GA15-10897S: Modulation of human skin cell responses to UVA radiation by silymarin components</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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