Metabolism of flavonolignans in human hepatocytes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73588074" target="_blank" >RIV/61989592:15110/18:73588074 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/18:00489013 RIV/61989592:15310/18:73588074
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S0731708517328790?token=536998082A11DD8D459B26DFEBDE755AAD012F73D9ED1423DF59A4F695FC5FD49A6BC2ED6C00E9FA26DCA8A590AEBAAA" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0731708517328790?token=536998082A11DD8D459B26DFEBDE755AAD012F73D9ED1423DF59A4F695FC5FD49A6BC2ED6C00E9FA26DCA8A590AEBAAA</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jpba.2018.01.048" target="_blank" >10.1016/j.jpba.2018.01.048</a>

Result language
angličtina
Original language name
Metabolism of flavonolignans in human hepatocytes
Original language description
Anotace: Biotransformation of silybin, 2,3-dehydrosilybin, silychristin, 2,3-dehydrosilychristin, silydianin, 2,3-dehydrosilydianin, isosilybin A and isosilybin B was examined using primary cultures of human hepatocytes and recombinant human cytochromes P450 (CYPs). The metabolites were analyzed by UPLC/MS. Eeach of the tested compounds was metabolized by one or more CYP enzymes which catalyzed O-demethylation, hydroxylation, hydrogenation and dehydrogenation reactions. In human hepatocytes, silybin, 2,3-dehydrosilybin, silychristin, 2,3-dehydrosilychristin, and isosilybins A and B were conjugated by sulfation or glucuronidation. Isosilybin A was also converted to a methyl derivative, while isosilybin B was hydroxylated and methylated. Silydianin and 2,3-dehydrosilydianin underwent hydrogenation and/or glucuronidation. In addition, the main metabolite of 2,3-dehydrosilydianin was a cleavage product corresponding to a loss of CO. We conclude that the hepatic biotransformation of flavonolignans primarily involves the phase II conjugation reactions, however in some cases the phase I reactions may also occur.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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