Real life adjuvant chemotherapy uptake and survival in patients with non-small cell lung cancer after complete resection

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73588285" target="_blank" >RIV/61989592:15110/18:73588285 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1080/03007995.2018.1490254" target="_blank" >http://dx.doi.org/10.1080/03007995.2018.1490254</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/03007995.2018.1490254" target="_blank" >10.1080/03007995.2018.1490254</a>

Result language

angličtina

Original language name

Real life adjuvant chemotherapy uptake and survival in patients with non-small cell lung cancer after complete resection

Original language description

Objectives: Adjuvant chemotherapy (AC) in non-small cell lung cancer (NSCLC) has become a standard of care in patients with stages IIA, IIB, and IIIA after complete tumor resection. Utilization and outcome of AC in routine practice is described in a few studies, with non-conclusive results. Materials and methods: This retrospective study included consecutive patients with NSCLC who underwent curative-intent surgery. Data of AC uptake in stages IB (tumor of 4 cm in diameter), II, and IIIA, and reasons of AC omission were evaluated according to medical records. Mortality risk among patients treated with surgery (only) and different types of AC in routine practice was compared. Results: AC was applied to 79% of patients with stages IB (tumor of 4 cm in diameter), II, and IIIA, and was associated with an improved median of overall survival (HR¼0.69; 95% CI¼0.44–1.06). Significantly longer survival was achieved in the sub-group treated with platinum and oral vinorelbine (HR¼0.575, 95% CI¼0.339–0.974), and the longest survival was among patients treated with oral vinorelbine and cisplatin (HR¼0.371, 95% CI¼0.168–0.820). Conclusions: AC utilization should be based on co-operation between surgeons, pneumo-oncologists, and patients. Rational use of AC offers better survival in routine practice.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30203 - Respiratory systems

Project

<a href="/en/project/NV16-32318A" target="_blank" >NV16-32318A: Non-invasive lung cancer diagnostics using proteomic biomarkers in exhaled breath condensate.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

CURRENT MEDICAL RESEARCH AND OPINION

ISSN

0300-7995

e-ISSN

—

Volume of the periodical

34

Issue of the periodical within the volume

9

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

1687-1694

UT code for WoS article

000441048500018

EID of the result in the Scopus database

2-s2.0-85049652060