Synthesis of Betulinic Acid Derivatives with Modified A-Rings and their Application as Potential Drug Candidates
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73590478" target="_blank" >RIV/61989592:15110/18:73590478 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/ajoc.201800163" target="_blank" >http://dx.doi.org/10.1002/ajoc.201800163</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ajoc.201800163" target="_blank" >10.1002/ajoc.201800163</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis of Betulinic Acid Derivatives with Modified A-Rings and their Application as Potential Drug Candidates
Original language description
This Focus Review summarizes recent advances in the synthesis of betulinic acid derivatives with modified A-rings. It also focuses on their application as potential therapeutic agents for the treatment of cancer and other diseases. Betulinic acid (BA) exhibits therapeutically interesting biological properties, including antitumor, anti-HIV, antiprotozoal, and hepato- or nephroprotective activity; however, its clinical use has been severely limited by its higher IC50 value and worse pharmacological parameters than the currently used drugs. On the other hand, semisynthetic analogues of BA are much better suited for potential clinical use. Among these analogues, compounds that contain a modified A-ring are the most promising. We hope that this Focus Review will serve as a guide for the synthesis of new BA derivatives with applications as drug candidates. A general audience may also find this Focus Review interesting, because it describes the structural motifs that are responsible for the observed bioactivities.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
<a href="/en/project/LO1304" target="_blank" >LO1304: Support of suistainability of the Institute of Molecular and Translational Medicine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Asian Journal of Organic Chemistry
ISSN
2193-5807
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
8
Country of publishing house
DE - GERMANY
Number of pages
19
Pages from-to
1542-1560
UT code for WoS article
000441415100008
EID of the result in the Scopus database
2-s2.0-85051420974