Contribution of Epstein-Barr Virus Latent Proteins to the Pathogenesis of Classical Hodgkin Lymphoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73590704" target="_blank" >RIV/61989592:15110/18:73590704 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3390/pathogens7030059" target="_blank" >http://dx.doi.org/10.3390/pathogens7030059</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/pathogens7030059" target="_blank" >10.3390/pathogens7030059</a>

Result language

angličtina

Original language name

Contribution of Epstein-Barr Virus Latent Proteins to the Pathogenesis of Classical Hodgkin Lymphoma

Original language description

Pathogenic viruses have evolved to manipulate the host cell utilising a variety of strategies including expression of viral proteins to hijack or mimic the activity of cellular functions. DNA tumour viruses often establish latent infection in which no new virions are produced, characterized by the expression of a restricted repertoire of so-called latent viral genes. These latent genes serve to remodel cellular functions to ensure survival of the virus within host cells, often for the lifetime of the infected individual. However, under certain circumstances, virus infection may contribute to transformation of the host cell; this event is not a usual outcome of infection. Here, we review how the Epstein–Barr virus (EBV), the prototypic oncogenic human virus, modulates host cell functions, with a focus on the role of the EBV latent genes in classical Hodgkin lymphoma.

Czech name

—

Czech description

—

Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

—

OECD FORD branch

30205 - Hematology

Project

<a href="/en/project/LO1304" target="_blank" >LO1304: Support of suistainability of the Institute of Molecular and Translational Medicine</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pathogens

ISSN

2076-0817

e-ISSN

—

Volume of the periodical

7

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

17

Pages from-to

1-17

UT code for WoS article

000447941500003

EID of the result in the Scopus database

2-s2.0-85049589205