Synthesis and characterization of new conjugates of betulin diacetate and bis(triphenysilyl) betulin with substituted triazoles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73591038" target="_blank" >RIV/61989592:15110/18:73591038 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/18:73591038
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs00706-017-2113-7" target="_blank" >https://link.springer.com/article/10.1007%2Fs00706-017-2113-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00706-017-2113-7" target="_blank" >10.1007/s00706-017-2113-7</a>

Result language
angličtina
Original language name
Synthesis and characterization of new conjugates of betulin diacetate and bis(triphenysilyl) betulin with substituted triazoles
Original language description
A set of 12 new conjugates of betulin diacetate and bis(triphenysilyl) betulin with substituted triazoles was synthesised via bromination of the position 30 followed by the substitution of the bromoderivatives with sodium azide and reaction of the 30-azidobetulin derivatives with organic alkynes via Huisgen 1,3-cycloaddition. All 15 new compounds (3 intermediates and 12 triazoles) were fully characterized, however, attempts to evaluate their cytotoxicity was impossible due to limited solubility in testing media
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10401 - Organic chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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