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Modification of Boc-Protected CAN508 via Acylation and Suzuki-Miyaura Coupling

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73591041" target="_blank" >RIV/61989592:15110/18:73591041 - isvavai.cz</a>

  • Alternative codes found

    RIV/61989592:15310/18:73591041

  • Result on the web

    <a href="https://www.mdpi.com/1420-3049/23/1/149/htm" target="_blank" >https://www.mdpi.com/1420-3049/23/1/149/htm</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/molecules23010149" target="_blank" >10.3390/molecules23010149</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Modification of Boc-Protected CAN508 via Acylation and Suzuki-Miyaura Coupling

  • Original language description

    The cyclin-dependent kinase inhibitor, CAN508, was protected with di-tert-butyl dicarbonate to access the amino-benzoylated pyrazoles. The bromo derivatives were further arylated by Suzuki-Miyaura coupling using the XPhos Pd G2 pre-catalyst. The coupling reaction provided generally the para-substituted benzoylpyrazoles in the higher yields than the meta-substituted ones. The Boc groups were only utilized as directing functionalities for the benzoylation step and were hydrolyzed under conditions of Suzuki-Miyaura coupling, which allowed for elimination of the additional deprotection step.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10401 - Organic chemistry

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    MOLECULES

  • ISSN

    1420-3049

  • e-ISSN

  • Volume of the periodical

    23

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    14

  • Pages from-to

    "149-1"-"149-14"

  • UT code for WoS article

    000425082500141

  • EID of the result in the Scopus database

    2-s2.0-85040520572