Infiltration of Prostate Cancer by CD204 and CD3 Cells Correlates with ERG Expression and TMPRSS2-ERG Gene Fusion

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73591088" target="_blank" >RIV/61989592:15110/18:73591088 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.14735/amko2018421" target="_blank" >http://dx.doi.org/10.14735/amko2018421</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14735/amko2018421" target="_blank" >10.14735/amko2018421</a>

Result language

angličtina

Original language name

Infiltration of Prostate Cancer by CD204 and CD3 Cells Correlates with ERG Expression and TMPRSS2-ERG Gene Fusion

Original language description

The aim of the study was to detect CD204 + and CD3 + cells in the infiltrate of benign prostatic hyperplasia, prostatic intraepithelial neoplasia and prostatic cancer in prostate specimens after radical prostatectomy. Another goal was to determine correlation of the intensity of the infiltration with ERG oncoprotein expression as well as with the presence of activating translocation TMPRSS2-ERG. Materials and Methods: To confirm the translocation, we used fluorescence in situ hybridization. Imunohistochemistry was used to detect the presence of ERG oncoprotein and for assesment of the number of CD204+ and CD3+ infiltrating cells. We determined the capability to infiltrate malignant structures according to differences in infiltration of benign and malignant prostate structures. Results: Biometric analysis confirmed that the number of CD204+ macrophages in the malignant structure was significantly higher than in the benign prostatic hyperplasia regardless of the fusion pattern. Increased infiltration by CD3+ cells was only detected in malignant structures of the prostate in a group with normal signal pattern and in a group with TMPRSS2-ERG fusion. Expression of ERG positively correlated with CD204+ and CD3+ cells infiltration of malignant structures only in cases where the TMPRSS2-ERG fusion was found.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

30217 - Urology and nephrology

Project

<a href="/en/project/LO1304" target="_blank" >LO1304: Support of suistainability of the Institute of Molecular and Translational Medicine</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Klinicka Onkologie

ISSN

0862-495X

e-ISSN

—

Volume of the periodical

31

Issue of the periodical within the volume

6

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

421-428

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-85058751990