Genome sequence of the opportunistic human pathogen Magnusiomyces capitatus
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73593438" target="_blank" >RIV/61989592:15110/18:73593438 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/19:00518828
Result on the web
<a href="https://link.springer.com/article/10.1007/s00294-018-0904-y" target="_blank" >https://link.springer.com/article/10.1007/s00294-018-0904-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00294-018-0904-y" target="_blank" >10.1007/s00294-018-0904-y</a>
Alternative languages
Result language
angličtina
Original language name
Genome sequence of the opportunistic human pathogen Magnusiomyces capitatus
Original language description
The yeast Magnusiomyces capitatus is an opportunistic human pathogen causing rare yet severe infections, especially in patients with hematological malignancies. Here, we report the 20.2 megabase genome sequence of an environmental strain of this species as well as the genome sequences of eight additional isolates from human and animal sources providing an insight into intraspecies variation. The distribution of single-nucleotide variants is indicative of genetic recombination events, supporting evidence for sexual reproduction in this heterothallic yeast. Using RNAseq-aided annotation, we identified genes for 6518 proteins including several expanded families such as kexin proteases and Hsp70 molecular chaperones. Several of these families are potentially associated with the ability of M. capitatus to infect and colonize humans. For the purpose of comparative analysis, we also determined the genome sequence of a closely related yeast, Magnusiomyces ingens. The genome sequences of M. capitatus and M. ingens exhibit many distinct features and represent a basis for further comparative and functional studies. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
10303 - Particles and field physics
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Genetics
ISSN
0172-8083
e-ISSN
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Volume of the periodical
65
Issue of the periodical within the volume
2
Country of publishing house
DE - GERMANY
Number of pages
22
Pages from-to
539-560
UT code for WoS article
000461396800028
EID of the result in the Scopus database
2-s2.0-85056814450