Differential Effects of Sustained Manual Pressure Stimulation According to Site of Action

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73594721" target="_blank" >RIV/61989592:15110/19:73594721 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15510/19:73594721 RIV/00098892:_____/19:N0000103

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fnins.2019.00722/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fnins.2019.00722/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnins.2019.00722" target="_blank" >10.3389/fnins.2019.00722</a>

Result language

angličtina

Original language name

Differential Effects of Sustained Manual Pressure Stimulation According to Site of Action

Original language description

Sustained pressure stimulation of the body surface has been used in several physiotherapeutic techniques, such as reflex locomotion therapy. Clinical observations of global motor responses and subsequent motor behavioral changes after stimulation in certain sites suggest modulation of central sensorimotor control, however, the neuroanatomical correlates remain undescribed. We hypothesized that different body sites would specifically influence the sensorimotor system during the stimulation. We tested the hypothesis using functional magnetic resonance imaging (fMRI) in thirty healthy volunteers (mean age 24.2) scanned twice during intermittent manual pressure stimulation, once at the right lateral heel according to reflex locomotion therapy, and once at the right lateral ankle (control site). A flexible modeling approach with finite impulse response basis functions was employed since non-canonical hemodynamic response was expected. Subsequently, a clustering algorithm was used to separate areas with differential timecourses. Stimulation at both sites induced responses throughout the sensorimotor system that could be mostly separated into two anti-correlated subsystems with transient positive or negative signal change and rapid adaptation, although in heel stimulation, insulo-opercular cortices and pons showed sustained activation. In direct voxel-wise comparison, heel stimulation was associated with significantly higher activation levels in the contralateral primary motor cortex and decreased activation in the posterior parietal cortex. Thus, we demonstrate that the manual pressure stimulation affects multiple brain structures involved in motor control and the choice of stimulation site impacts the shape and amplitude of the blood oxygenation level-dependent response. We further discuss the relationship between the affected structures and behavioral changes after reflex locomotion therapy.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/GA14-22572S" target="_blank" >GA14-22572S: Central and autonomic nervous system correlates of prolonged peripheral stimulation in the human</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Neuroscience

ISSN

1662-453X

e-ISSN

—

Volume of the periodical

13

Issue of the periodical within the volume

722

Country of publishing house

CH - SWITZERLAND

Number of pages

14

Pages from-to

1-14

UT code for WoS article

000475934200002

EID of the result in the Scopus database

2-s2.0-85073881614