Amino-BODIPY as the Ratiometric Fluorescent Sensor for Monitoring Drug Release or “Power Supply” Selector for Molecular Electronics

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73597559" target="_blank" >RIV/61989592:15110/19:73597559 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/19:73597559
Result on the web
<a href="https://pubs.rsc.org/en/content/articlepdf/2019/ra/c9ra03472b" target="_blank" >https://pubs.rsc.org/en/content/articlepdf/2019/ra/c9ra03472b</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/C9RA03472B" target="_blank" >10.1039/C9RA03472B</a>

Result language
angličtina
Original language name
Amino-BODIPY as the Ratiometric Fluorescent Sensor for Monitoring Drug Release or “Power Supply” Selector for Molecular Electronics
Original language description
The glutathione cleavable conjugates of amino-BODIPY dye with model drugs have been tested for monitoring the drug release via ratiometric fluorescence based on two excitation and one emission wavelengths. As the self-immolative linker was used for the construction of conjugates, free amino-BODIPY was released with the drug. Different excitation profiles of the dye before and after conjugate cleavage and similar emission wavelengths that enabled monitoring the release of the drug via the OFF-ON effect were successfully tested inside the cancer cells. UV/VIS spectrometry could be used in the quantification of the conjugate/drug in an analyte irrespective of the cleavage grade. As the system functionality was based only on the altered acylamino-BODIPY present in the conjugate to amino-BODIPY released during the cleavage, the method could be applied as a ratiometric fluorescence theranostic system to other non-fluorescent drugs. Therefore, the present conjugates demonstrated their potential application in molecular electronics as a “power supply” selector enabling the application of two power sources for one “bulb” to maintain its light intensity.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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