Improving The Primary Care Management Of Preschool Children With Recurrent Acute Respiratory Tract Infections In The Czech Republic: Prompt Use Of Erdosteine Can Reduce Antibiotic Prescribing

Result code in IS VaVaI

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Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Improving The Primary Care Management Of Preschool Children With Recurrent Acute Respiratory Tract Infections In The Czech Republic: Prompt Use Of Erdosteine Can Reduce Antibiotic Prescribing

Original language description

Acute Respiratory Tract Infections (RTIs) are very common in children and, although they are predominantly viral in origin and self-limiting, are a major cause of inappropriate antibiotic prescribing in primary care. Numerous strategies and interventions are being developed to optimize antibiotic prescribing for acute RTIs. In this article, we review the evidence that early use of erdosteine in children with acute RTIs of viral origin may reduce unnecessary antibiotic prescribing in the primary care setting. Erdosteine is an oral mucolytic agent that also has antibacterial and anti-inflammatory effects which are relevant for the treatment of respiratory diseases. Several randomised clinical studies in children with acute lower RTIs have shown that combined treatment with erdosteine and an antibiotic enables a more rapid improvement in symptoms, particularly cough, than antibiotic therapy alone. We describe the ERICA study, a non-interventional, observational, multicentre study performed in routine general practice in the Czech Republic over the 2014?2015 winter season in 342 children with a history of recurrent RTIs (≥2) treated with antibiotics in the previous winter season. During the monitored season, all children were prescribed erdosteine at initial presentation for an acute viral RTI, but only 21 (4.4%) of the 473 RTIs resulted in an antibiotic prescription. The mean number of antibiotics used was 0.06 versus 2.32 in the previous season (p&lt;0.001). Also, 73.4% experienced only one RTI during the season. This is the first real-world primary care study to show that prompt use of erdosteine at the initial signs of an acute RTI of presumed viral origin results in a large reduction in antibiotic use and fewer respiratory infections in children with a history of recurrent RTI, many of whom were preschool age and had allergic disorders. Further studies with erdosteine are needed to confirm these findings.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

30209 - Paediatrics

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Quality in Primary Care

ISSN

1479-1072

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

36-42

UT code for WoS article

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EID of the result in the Scopus database

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