All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Comparison of lymphocyte immune phenotypes in bronchoalveolar lavage of non-smoking patients with sarcoidosis and other interstitial lung diseases

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73598463" target="_blank" >RIV/61989592:15110/19:73598463 - isvavai.cz</a>

  • Result on the web

    <a href="http://jtd.amegroups.com/article/view/29635/21451" target="_blank" >http://jtd.amegroups.com/article/view/29635/21451</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.21037/jtd.2019.06.05" target="_blank" >10.21037/jtd.2019.06.05</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Comparison of lymphocyte immune phenotypes in bronchoalveolar lavage of non-smoking patients with sarcoidosis and other interstitial lung diseases

  • Original language description

    Background: Bronchoalveolar lavage (BAL) as complementary method is still used as ancillary tool in diagnosis of interstitial lung diseases. lbbacco smoking has been described to affect the BAL, lavage cellular profile. lb our knowledge, only few reports have so far investigated CD3(+)CD4(+) and CD3(+)CD8(+) lymphocyte subsets in non-smoking sarcoidosis patients additionally stratified according to CXR stage, and compared them to other non-smoking patients with interstitial lung diseases (ILDs). Methods: We compared lymphocytes immune phenotypes, subsets, with CD3(+), CD3(+)CD4(+) and CD3(+)TD8(+) cell markers, in the non-smoking subjects (n=297) including the patients with pulmonary sarcoidosis (S), idiopathic pulmonary fibrosis (IPF) (n=22), hypersensitivity pneumonitis (HP) (n=15), other interstitial idiopathic pneumonias (OIIPs) (n=39). According to prognosis, the patients with S were divided into four groups: 18 patients with Lofgren&apos;s syndrome (LS) in chest X-ray (CXR) &lt;= 1 stage, 64 patients without LS in CXR &lt;= 1 stage, 113 patients in CXR 2 stage and 26 patients with advanced CXR &gt;= 3 stage. Results: After the use of false discovery rate (FDR) correction, relative numbers (%) of CD3(+), CD3(+)CD4(+), CD3(+)CD8(+) and CD3(+)CD4(+)/CD3(+)CD8(+) ratio showed the most significant differences between the nonsmokers with S (both with/without LS) and the non-smokers with other ILDs (IPF, OIIPs, HP). These lymphocytes subsets were further altered in the non-smokers with CXR stage 2 compared to the nonsmokers with other ILDs (IPF, OIIPs, HP). We did not observe any differences in these lymphocyte subsets and CD3(+)CD4(+)/CD3(+)CD8(+). ratio between the non-smokers with advanced sarcoidosis stage (CXR &gt;= 3) and the non-smokers with IPF. Conclusions: Our data on the non-smokers confirmed the presence of the typical BAL cellular profile in sarcoidosis. The BAL cellular profile was helpful namely for differentiation of less advanced sarcoidosis. Its definite diagnostic utility should be the subject of further clinical studies with large numbers of the well characterized patients taking into consideration other clinical factors influencing BAL, cellular profile, such as smoking or treatment.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30203 - Respiratory systems

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Thoracic Disease

  • ISSN

    2072-1439

  • e-ISSN

  • Volume of the periodical

    11

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    HK - HONG KONG

  • Number of pages

    10

  • Pages from-to

    2287-2296

  • UT code for WoS article

    000473287500023

  • EID of the result in the Scopus database

    2-s2.0-85068935445