Comparison of lymphocyte immune phenotypes in bronchoalveolar lavage of non-smoking patients with sarcoidosis and other interstitial lung diseases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73598463" target="_blank" >RIV/61989592:15110/19:73598463 - isvavai.cz</a>
Result on the web
<a href="http://jtd.amegroups.com/article/view/29635/21451" target="_blank" >http://jtd.amegroups.com/article/view/29635/21451</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21037/jtd.2019.06.05" target="_blank" >10.21037/jtd.2019.06.05</a>
Alternative languages
Result language
angličtina
Original language name
Comparison of lymphocyte immune phenotypes in bronchoalveolar lavage of non-smoking patients with sarcoidosis and other interstitial lung diseases
Original language description
Background: Bronchoalveolar lavage (BAL) as complementary method is still used as ancillary tool in diagnosis of interstitial lung diseases. lbbacco smoking has been described to affect the BAL, lavage cellular profile. lb our knowledge, only few reports have so far investigated CD3(+)CD4(+) and CD3(+)CD8(+) lymphocyte subsets in non-smoking sarcoidosis patients additionally stratified according to CXR stage, and compared them to other non-smoking patients with interstitial lung diseases (ILDs). Methods: We compared lymphocytes immune phenotypes, subsets, with CD3(+), CD3(+)CD4(+) and CD3(+)TD8(+) cell markers, in the non-smoking subjects (n=297) including the patients with pulmonary sarcoidosis (S), idiopathic pulmonary fibrosis (IPF) (n=22), hypersensitivity pneumonitis (HP) (n=15), other interstitial idiopathic pneumonias (OIIPs) (n=39). According to prognosis, the patients with S were divided into four groups: 18 patients with Lofgren's syndrome (LS) in chest X-ray (CXR) <= 1 stage, 64 patients without LS in CXR <= 1 stage, 113 patients in CXR 2 stage and 26 patients with advanced CXR >= 3 stage. Results: After the use of false discovery rate (FDR) correction, relative numbers (%) of CD3(+), CD3(+)CD4(+), CD3(+)CD8(+) and CD3(+)CD4(+)/CD3(+)CD8(+) ratio showed the most significant differences between the nonsmokers with S (both with/without LS) and the non-smokers with other ILDs (IPF, OIIPs, HP). These lymphocytes subsets were further altered in the non-smokers with CXR stage 2 compared to the nonsmokers with other ILDs (IPF, OIIPs, HP). We did not observe any differences in these lymphocyte subsets and CD3(+)CD4(+)/CD3(+)CD8(+). ratio between the non-smokers with advanced sarcoidosis stage (CXR >= 3) and the non-smokers with IPF. Conclusions: Our data on the non-smokers confirmed the presence of the typical BAL cellular profile in sarcoidosis. The BAL cellular profile was helpful namely for differentiation of less advanced sarcoidosis. Its definite diagnostic utility should be the subject of further clinical studies with large numbers of the well characterized patients taking into consideration other clinical factors influencing BAL, cellular profile, such as smoking or treatment.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30203 - Respiratory systems
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Thoracic Disease
ISSN
2072-1439
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
6
Country of publishing house
HK - HONG KONG
Number of pages
10
Pages from-to
2287-2296
UT code for WoS article
000473287500023
EID of the result in the Scopus database
2-s2.0-85068935445