Periprosthetic osteolysis: Mechanisms, prevention and treatment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73599386" target="_blank" >RIV/61989592:15110/19:73599386 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2077-0383/8/12/2091/htm" target="_blank" >https://www.mdpi.com/2077-0383/8/12/2091/htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/jcm8122091" target="_blank" >10.3390/jcm8122091</a>

Result language

angličtina

Original language name

Periprosthetic osteolysis: Mechanisms, prevention and treatment

Original language description

Clinical studies, as well as in vitro and in vivo experiments have demonstrated that byproducts from joint replacements induce an inflammatory reaction that can result in periprosthetic osteolysis (PPOL) and aseptic loosening (AL). Particle-stimulated macrophages and other cells release cytokines, chemokines, and other pro-inflammatory substances that perpetuate chronic inflammation, induce osteoclastic bone resorption and suppress bone formation. Differentiation, maturation, activation, and survival of osteoclasts at the bone–implant interface are under the control of the receptor activator of nuclear factor kappa-Β ligand (RANKL)-dependent pathways, and the transcription factors like nuclear factor κB (NF-κB) and activator protein-1 (AP-1). Mechanical factors such as prosthetic micromotion and oscillations in fluid pressures also contribute to PPOL. The treatment for progressive PPOL is only surgical. In order to mitigate ongoing loss of host bone, a number of non-operative approaches have been proposed. However, except for the use of bisphosphonates in selected cases, none are evidence based. To date, the most successful and effective approach to preventing PPOL is usage of wear-resistant bearing couples in combination with advanced implant designs, reducing the load of metallic and polymer particles. These innovations have significantly decreased the revision rate due to AL and PPOL in the last decade.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30211 - Orthopaedics

Project

<a href="/en/project/NV16-31852A" target="_blank" >NV16-31852A: Prediction for reoperation in patients with THA and TKA based on immunogenetic signature: development of risk calculator for routine clinical practice</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Clinical Medicine

ISSN

2077-0383

e-ISSN

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Volume of the periodical

86

Issue of the periodical within the volume

12

Country of publishing house

CH - SWITZERLAND

Number of pages

22

Pages from-to

"nestránkováno"

UT code for WoS article

000506640400064

EID of the result in the Scopus database

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