Non-homogeneous dissolution of drug affects the quality of parenteral treatment

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73600910" target="_blank" >RIV/61989592:15110/19:73600910 - isvavai.cz</a>
Result on the web
<a href="https://www.researchgate.net/publication/332765575_NON-HOMOGENEOUS_DISSOLUTION_OF_DRUG_AFFECTS_THE_QUALITY_OF_PARENTERAL_TREATMENT" target="_blank" >https://www.researchgate.net/publication/332765575_NON-HOMOGENEOUS_DISSOLUTION_OF_DRUG_AFFECTS_THE_QUALITY_OF_PARENTERAL_TREATMENT</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.32383/appdr/99297" target="_blank" >10.32383/appdr/99297</a>

Result language
angličtina
Original language name
Non-homogeneous dissolution of drug affects the quality of parenteral treatment
Original language description
Intravenous administration of the drugs poses risks as treatment failure or higher incidence ofunwanted effects. There are many critical steps in the preparation of infusion. The aim of this experimentalstudy was to evaluate the effect of careful or careless infusion preparation on meropenem concentration in theinfusion. Three different ways for the preparation of the infusion solution were compared. The first third of thebags were inverted ten times after meropenem addition. The second third of the bags were hung up aftermeropenem addition without shaking, and the last third of the bags were first hang up on the holder and thenthe antibiotic was added. Samples of meropenem were collected regularly and were used for the subsequentHPLC analysis. There are significant differences in meropenem concentration depending on the preparation.The variation of meropenem concentration is significantly higher where inadequate homogenization was used.Our results showed that proper inverting of the infusion container provides the homogenous infusion solution.Late drug addition or inadequate mixing may have a clinical impact on the given dose, especially in continu-ously administered drugs
Czech name
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Czech description
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Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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