High CXCR3 on leukemic cells distinguishes IgHVmut from IgHVunmut in chronic lymphocytic leukemia: evidence from CD5high and CD5low clones
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F20%3A73600899" target="_blank" >RIV/61989592:15110/20:73600899 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/20:N0000143 RIV/61989100:27240/20:10247277
Result on the web
<a href="https://www.hindawi.com/journals/jir/2020/7084268/" target="_blank" >https://www.hindawi.com/journals/jir/2020/7084268/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2020/7084268" target="_blank" >10.1155/2020/7084268</a>
Alternative languages
Result language
angličtina
Original language name
High CXCR3 on leukemic cells distinguishes IgHVmut from IgHVunmut in chronic lymphocytic leukemia: evidence from CD5high and CD5low clones
Original language description
Despite the shared pattern of surface antigens, neoplastic cells in chronic lymphocytic leukemia (CLL) are highly heterogeneous in CD5 expression, a marker linked to a proliferative pool of neoplastic cells. To further characterize CD5high and CD5low neoplastic cells, we assessed the chemokine receptors (CCR5, CCR7, CCR10, CXCR3, CXCR4, CXCR5) and adhesion molecules (CD54, CD62L, CD49d) on the CD5high and CD5low subpopulations, defined by CD5/CD19 co-expression, in peripheral blood of CLL patients (n=60) subgrouped according to the IgHV mutational status (IgHVmut, n=24; IgHVunmut, n=36). CD5high subpopulation showed a high percentage of CXCR3 (P<0.001), CCR10 (P=0.001), and CD62L (P=0.031) and high levels of CXCR5 (P=0.005), CCR7 (P=0.013) compared to CD5low cells expressing high CXCR4 (P<0.001). Comparing IgHVmut and IgHVunmut patients, high levels of CXCR3 on CD5high and CD5low subpopulations were detected in the IgHVmut patients; with better discrimination in CD5low subpopulation. Levels of CXCR3 on CD5low subpopulation were associated with time to the next treatment, thus further confirming its prognostic value. Taken together, our analysis revealed higher CXCR3 expression on both CD5high and CD5low neoplastic cells in IgHVmut with a better prognosis compared to IgHVunmut patients. Contribution of CXCR3 to CLL pathophysiology and its suitability for prognostication and therapeutic exploitation deserves future investigations.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
<a href="/en/project/NV16-32339A" target="_blank" >NV16-32339A: Impact of functional polymorphisms influencing inflammation and oxidative stress on outcome and selection of treatment in chronic lymphocytic leukemia</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Immunology Research
ISSN
2314-8861
e-ISSN
—
Volume of the periodical
2020
Issue of the periodical within the volume
JUNE
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
"'7084268(1)'"-"'7084268(10)'"
UT code for WoS article
000546050900001
EID of the result in the Scopus database
2-s2.0-85087568161