Fluorinated derivatives of 2-phenyl-3-hydroxy-4(1H)-quinolinone as tubulin polymerization inhibitors

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F20%3A73601222" target="_blank" >RIV/61989592:15110/20:73601222 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/20:73601222
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0223523420301434?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0223523420301434?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejmech.2020.112176" target="_blank" >10.1016/j.ejmech.2020.112176</a>

Result language
angličtina
Original language name
Fluorinated derivatives of 2-phenyl-3-hydroxy-4(1H)-quinolinone as tubulin polymerization inhibitors
Original language description
The previous studies of the derivatives of 2-phenyl-3-hydroxy-4(1H)-quinolinone (3-HQs) recognized these compounds to exhibit anticancer activity in vitro in the native state [[1], [2], [3], [4], [5], [6], [7]] or as mixed-ligand complexes with various metals [[8], [9], [10], [11], [12]]. Although these studies described the number of derivatives to have exciting anticancer activity, only two papers revealed a possible molecular target. In the first study, Sui et al. [13] reported the inhibition of topoisomerase as an expected molecular target. The authors found some derivatives with higher activity against mammalian topoisomerase than ellipticine. Recently published interaction of other 3-HQs derivatives with elongation factor eEF1A1 inside the cancer cells revealed another possible mechanism of anticancer activity [14].
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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