Synthesis and photodynamic properties of pyrazole-indole hybrids in the human skin melanoma cell line G361

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F20%3A73602382" target="_blank" >RIV/61989592:15110/20:73602382 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/20:73602382 RIV/61389030:_____/20:00532929
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0143720820313632?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0143720820313632?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.dyepig.2020.108666" target="_blank" >10.1016/j.dyepig.2020.108666</a>

Result language
angličtina
Original language name
Synthesis and photodynamic properties of pyrazole-indole hybrids in the human skin melanoma cell line G361
Original language description
Three conjugated pyrazole-indole hybrids, 5, 7 and 10, were synthesized from easily accessible 3-(hexyloxy)-1-phenyl-1H-pyrazole-4-carbaldehyde 1 and 5-iodo-3,3-dimethyl-2-phenyl-3H-indole 4 employing olefination reactions (Wittig, Ramirez), Vilsmeier-Haack formylation and palladium-catalysed cross coupling reactions (ligand-free Heck, Sonogashira). The compounds displayed no cytotoxicity in the melanoma cell line G361 unless irradiated with visible blue light (414 nm), and the potency of the compounds increased with light intensity.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
20402 - Chemical process engineering

Project
<a href="/en/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molecular, cellular and clinical approach to healthy ageing</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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