Impact of Hormone Receptor Status on the Behaviour of HER2 Breast Cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F20%3A73602726" target="_blank" >RIV/61989592:15110/20:73602726 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/20:00117213 RIV/00216208:11110/20:10417331 RIV/00216208:11120/20:43920757 RIV/00216208:11150/20:10417331 and 4 more
Result on the web
<a href="http://iv.iiarjournals.org/content/34/6/3441.full.pdf" target="_blank" >http://iv.iiarjournals.org/content/34/6/3441.full.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21873/invivo.12183" target="_blank" >10.21873/invivo.12183</a>
Alternative languages
Result language
angličtina
Original language name
Impact of Hormone Receptor Status on the Behaviour of HER2 Breast Cancer
Original language description
Background/Aim: The study aimed to evaluate differences in the overall survival of HER2+ breast cancer patients treated with regard to their hormone receptors negativity or positivity. We evaluated a cohort of patients treated with trastuzumab in the Czech Republic. Patients and Methods: The present study is a retrospective analysis of patients whose data were recorded in a nationwide non-interventional, post-authorisation database BREAST. After propensity score matching of data, the cohort included 4,532 patients. Results: A significant difference in overall survival (OS) of the entire cohort was found between patients with and without hormone dependence. The OS was significantly higher in the group of patients with hormone receptor-positive (HR+) tumours in the following cohorts: patients treated with neoadjuvant therapy, patients with advanced disease, G2 tumours, stage III and IV and in patients with stage II and III of G2 tumours. Conclusion: Increased OS rates were found in several subgroups of patients with HR+/HER2+ tumours compared to those with HR/HER2+ tumours. Better outcomes of HR+/HER2+ patients were only observed in the first four/five years of follow-up, and the differences disappeared over time.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
IN VIVO
ISSN
0258-851X
e-ISSN
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Volume of the periodical
34
Issue of the periodical within the volume
6
Country of publishing house
GR - GREECE
Number of pages
9
Pages from-to
3441-3449
UT code for WoS article
000587929100043
EID of the result in the Scopus database
2-s2.0-85095589011