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Precision medicine in medical oncology: hope, disappointment and reality

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F20%3A73602831" target="_blank" >RIV/61989592:15110/20:73602831 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.degruyter.com/view/journals/cclm/58/9/article-p1427.xml" target="_blank" >https://www.degruyter.com/view/journals/cclm/58/9/article-p1427.xml</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1515/cclm-2020-0231" target="_blank" >10.1515/cclm-2020-0231</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Precision medicine in medical oncology: hope, disappointment and reality

  • Original language description

    During the past 20 years, targeted therapy based on the understanding of tumor biology has been complementing or even replacing cytotoxic agents that have dominated pharmacotherapy of cancer since the conception of medical oncology. Unfortunately, the fact that targeted therapies with potential to induce cure or at least substantially prolong survival are still not available for many common solid tumors results in skepticism or even nihilism. On the one hand, biomarker research is not keeping pace with the introduction of new agents, while on the other hand, effective drugs are still not available for many potential molecular targets associated with malignant transformation and tumor progression. However, targeted therapies have already transformed the natural history and clinical outcomes not only in patients with rare malignancies like gastrointestinal stromal tumor but also with many common tumors, e.g. breast cancer, malignant melanoma, non-small cell lung cancer or renal cell carcinoma. For further advances, a multidisciplinary effort is indispensible that should, above all, involve the collaboration of medical oncology and laboratory medicine.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30204 - Oncology

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    CLINICAL CHEMISTRY AND LABORATORY MEDICINE

  • ISSN

    1434-6621

  • e-ISSN

  • Volume of the periodical

    58

  • Issue of the periodical within the volume

    9

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    5

  • Pages from-to

    1427-1431

  • UT code for WoS article

    000560715100016

  • EID of the result in the Scopus database

    2-s2.0-85083515757