Precision medicine in medical oncology: hope, disappointment and reality
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F20%3A73602831" target="_blank" >RIV/61989592:15110/20:73602831 - isvavai.cz</a>
Result on the web
<a href="https://www.degruyter.com/view/journals/cclm/58/9/article-p1427.xml" target="_blank" >https://www.degruyter.com/view/journals/cclm/58/9/article-p1427.xml</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/cclm-2020-0231" target="_blank" >10.1515/cclm-2020-0231</a>
Alternative languages
Result language
angličtina
Original language name
Precision medicine in medical oncology: hope, disappointment and reality
Original language description
During the past 20 years, targeted therapy based on the understanding of tumor biology has been complementing or even replacing cytotoxic agents that have dominated pharmacotherapy of cancer since the conception of medical oncology. Unfortunately, the fact that targeted therapies with potential to induce cure or at least substantially prolong survival are still not available for many common solid tumors results in skepticism or even nihilism. On the one hand, biomarker research is not keeping pace with the introduction of new agents, while on the other hand, effective drugs are still not available for many potential molecular targets associated with malignant transformation and tumor progression. However, targeted therapies have already transformed the natural history and clinical outcomes not only in patients with rare malignancies like gastrointestinal stromal tumor but also with many common tumors, e.g. breast cancer, malignant melanoma, non-small cell lung cancer or renal cell carcinoma. For further advances, a multidisciplinary effort is indispensible that should, above all, involve the collaboration of medical oncology and laboratory medicine.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
ISSN
1434-6621
e-ISSN
—
Volume of the periodical
58
Issue of the periodical within the volume
9
Country of publishing house
DE - GERMANY
Number of pages
5
Pages from-to
1427-1431
UT code for WoS article
000560715100016
EID of the result in the Scopus database
2-s2.0-85083515757