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Deep Brain Stimulation Effects on Gait Pattern in Advanced Parkinson’s Disease Patients

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F20%3A73603280" target="_blank" >RIV/61989592:15110/20:73603280 - isvavai.cz</a>

  • Alternative codes found

    RIV/00098892:_____/20:N0000128

  • Result on the web

    <a href="https://www.frontiersin.org/articles/10.3389/fnins.2020.00814/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fnins.2020.00814/full</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3389/fnins.2020.00814" target="_blank" >10.3389/fnins.2020.00814</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Deep Brain Stimulation Effects on Gait Pattern in Advanced Parkinson’s Disease Patients

  • Original language description

    Background Gait disturbance accompanies many neurodegenerative diseases; it is characteristic for Parkinson&apos;s disease (PD). Treatment of advanced PD often includes deep brain stimulation (DBS) of the subthalamic nucleus. Regarding gait, previous studies have reported non-significant or conflicting results, possibly related to methodological limitations. Objective The objective of this prospective study was to assess the effects of DBS on biomechanical parameters of gait in patients with PD. Methods Twenty-one patients with advanced PD participated in this prospective study. Gait was examined in all patients using the Zebris FDM-T pressure-sensitive treadmill (Isny, Germany) before DBS implantation and after surgery immediately, further immediately after the start of neurostimulation, and 3 months after neurostimulator activation. We assessed spontaneous gait on a moving treadmill at different speeds. Step length, stance phase of both lower limbs, double-stance phase, and cadence were evaluated. Results In this study, step length increased, allowing the cadence to decrease. Double-stance phase duration, that is, the most sensitive parameter of gait quality and unsteadiness, was reduced, in gait at a speed of 4.5 km/h and in the narrow-based gaits at 1 km/h (tandem gait), which demonstrates improvement. Conclusion This study suggests positive effects of DBS treatment on gait in PD patients. Improvement was observed in several biomechanical parameters of gait.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30210 - Clinical neurology

Result continuities

  • Project

  • Continuities

    N - Vyzkumna aktivita podporovana z neverejnych zdroju

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Frontiers in Neuroscience

  • ISSN

    1662-453X

  • e-ISSN

  • Volume of the periodical

    14

  • Issue of the periodical within the volume

    August 2020

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    9

  • Pages from-to

    "'814(1)'"-"'814(9)'"

  • UT code for WoS article

    000566222800001

  • EID of the result in the Scopus database

    2-s2.0-85090009062