The EUTOS long-term survival (ELTS) score is superior to the Sokal score for predicting survival in chronic myeloid leukemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F20%3A73603491" target="_blank" >RIV/61989592:15110/20:73603491 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/20:00116177 RIV/65269705:_____/20:00073036
Result on the web
<a href="http://www.nature.com/articles/s41375-020-0931-9" target="_blank" >http://www.nature.com/articles/s41375-020-0931-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41375-020-0931-9" target="_blank" >10.1038/s41375-020-0931-9</a>
Alternative languages
Result language
angličtina
Original language name
The EUTOS long-term survival (ELTS) score is superior to the Sokal score for predicting survival in chronic myeloid leukemia
Original language description
Prognostic scores support clinicians in selecting risk-adjusted treatments and in comparatively assessing different results. For patients with chronic-phase chronic myeloid leukemia (CML), four baseline prognostic scores are commonly used. Our aim was to compare the prognostic performance of the scores and to arrive at an evidence-based score recommendation. In 2949 patients not involved in any score development, higher hazard ratios and concordance indices in any comparison demonstrated the best discrimination of long-term survival with the ELTS score. In a second step, of 5154 patients analyzed to investigate risk group classification differences, 23% (n = 1197) were allocated to high-risk by the Sokal score. Of the 1197 Sokal high-risk patients, 56% were non-high-risk according to the ELTS score and had a significantly more favorable long-term survival prognosis than the 526 high-risk patients according to both scores. The Sokal score identified too many patients as high-risk and relatively few (40%) as low-risk (versus 60% with the ELTS score). Inappropriate risk classification jeopardizes optimal treatment selection. The ELTS score outperformed the Sokal score, the Euro, and the EUTOS score regarding risk group discrimination. The recent recommendation of the European LeukemiaNet for preferred use of the ELTS score was supported with significant statistical evidence.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30205 - Hematology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
LEUKEMIA
ISSN
0887-6924
e-ISSN
—
Volume of the periodical
34
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
2138-2149
UT code for WoS article
000544139100003
EID of the result in the Scopus database
2-s2.0-85087036221