Cortical somatosensory processing after botulinum toxin therapy in post-stroke spasticity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F21%3A73607908" target="_blank" >RIV/61989592:15110/21:73607908 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/21:N0000054
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238289/pdf/medi-100-e26356.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238289/pdf/medi-100-e26356.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/MD.0000000000026356" target="_blank" >10.1097/MD.0000000000026356</a>
Alternative languages
Result language
angličtina
Original language name
Cortical somatosensory processing after botulinum toxin therapy in post-stroke spasticity
Original language description
Abstract In dystonic and spastic movement disorders, abnormalities of motor control and somatosensory processing as well as cortical modulations associated with clinical improvement after botulinum toxin A (BoNT-A) treatment have been reported, but electrophysiological evidence remains controversial. In the present observational study, we aimed to uncover central correlates of post-stroke spasticity (PSS) and BoNT-A-related changes in the sensorimotor cortex by investigating the cortical components of somatosensory evoked potentials (SEPs). Thirty-one chronic stroke patients with PSS of the upper limb were treated with BoNT-A application into the affected muscles and physiotherapy. Clinical and electrophysiological evaluations were performed just before BoNT-A application (W0), then 4 weeks (W4) and 11weeks (W11) later. PSS was evaluated with the modified Ashworth scale (MAS). Median nerve SEPs were examined in both upper limbs with subsequent statistical analysis of the peak-to-peak amplitudes of precentral P22/N30 and postcentral N20/P23 components. At baseline (W0), postcentral SEPs were significantly lower over the affected cortex. At follow up, cortical SEPs did not show any significant changes attributable to BoNT-A and/or physiotherapy, despite clear clinical improvement. Our results imply that conventional SEPs are of limited value in evaluating cortical changes after BoNT-A treatment and further studies are needed to elucidate its central actions. Abbreviations: ADL = activities of daily living, BoNT-A = botulinum toxin A, CNS = central nervous system, fMRI = functional magnetic resonance imaging, IQR = interquartile range, MAS = modified Ashworth scale, PPC = posterior parietal cortex, PSS = post-stroke spasticity, SD = standard deviation, SEPs = somatosensory evoked potentials.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
<a href="/en/project/NV17-29452A" target="_blank" >NV17-29452A: Sensorimotor network modulation by targeted therapy of post-stroke spasticity</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
MEDICINE
ISSN
0025-7974
e-ISSN
—
Volume of the periodical
25
Issue of the periodical within the volume
100
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
"nestránkováno"
UT code for WoS article
000664672200028
EID of the result in the Scopus database
2-s2.0-85109017978