Dual Effect of Taxifolin on ZEB2 Cancer Signaling in HepG2 Cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F21%3A73608580" target="_blank" >RIV/61989592:15110/21:73608580 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14510/21:00121251
Result on the web
<a href="https://www.mdpi.com/1420-3049/26/5/1476/htm" target="_blank" >https://www.mdpi.com/1420-3049/26/5/1476/htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/molecules26051476" target="_blank" >10.3390/molecules26051476</a>
Alternative languages
Result language
angličtina
Original language name
Dual Effect of Taxifolin on ZEB2 Cancer Signaling in HepG2 Cells
Original language description
Polyphenols, secondary metabolites of plants, exhibit different anti-cancer and cytoprotective properties such as anti-radical, anti-angiogenic, anti-inflammation, or cardioprotective. Some of these activities could be linked to modulation of miRNAs expression. MiRNAs play an important role in posttranscriptional regulation of their target genes that could be important within cell signalling or preservation of cell homeostasis, e.g., cell survival/apoptosis. We evaluated the influence of a non-toxic concentration of taxifolin and quercetin on the expression of majority human miRNAs via Affymetrix GeneChip™ miRNA 3.0 Array. For the evaluation we used two cell models corresponding to liver tissue, Hep G2 and primary human hepatocytes. The array analysis identified four miRNAs, miR-153, miR-204, miR-211, and miR-377-3p, with reduced expression after taxifolin treatment. All of these miRNAs are linked to modulation of ZEB2 expression in various models. Indeed, ZEB2 protein displayed upregulation after taxifolin treatment in a dose dependent manner. However, the modulation did not lead to epithelial mesenchymal transition. Our data show that taxifolin inhibits Akt phosphorylation, thereby diminishing ZEB2 signalling that could trigger carcinogenesis. We conclude that biological activity of taxifolin may have ambiguous or even contradictory outcomes because of non-specific effect on the cell.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
MOLECULES
ISSN
1420-3049
e-ISSN
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Volume of the periodical
26
Issue of the periodical within the volume
5
Country of publishing house
CH - SWITZERLAND
Number of pages
20
Pages from-to
"'1476(1)'"-"'1476(20)'"
UT code for WoS article
000628430300001
EID of the result in the Scopus database
2-s2.0-85103862932