Somatostatin Receptor Subtype Expression in Patients with Acromegaly and Complicated Clinical Course

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F21%3A73610012" target="_blank" >RIV/61989592:15110/21:73610012 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.3390/diagnostics11061050" target="_blank" >https://doi.org/10.3390/diagnostics11061050</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/diagnostics11061050" target="_blank" >10.3390/diagnostics11061050</a>

Result language

angličtina

Original language name

Somatostatin Receptor Subtype Expression in Patients with Acromegaly and Complicated Clinical Course

Original language description

Somatostatin analogues are considered to be the first line of treatment in acromegaly. Somatostatin analogues of the first generation mainly target the somatostatin receptor (SSTR) subtype 2 and have been proven efficient in the majority of patients with acromegaly. Pasireotide was the first somatostatin analogue also substantially targeting the SSTR subtype 5. An efficient drug for Cushing’s disease tailored to suboptimal-responding patients with acromegaly then became available. We immunohistochemically investigated SSTR subtypes expression in pituitary adenomas from operated acromegaly patients with clinical relapse and a complicated clinical course. Patients received pasireotide in the course of their disease. The predictive value of SSTR subtypes immunhistochemical analysis for the therapeutic response is discussed.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Diagnostics

ISSN

2075-4418

e-ISSN

—

Volume of the periodical

11

Issue of the periodical within the volume

6

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

"nestránkováno"

UT code for WoS article

000666940100001

EID of the result in the Scopus database

2-s2.0-85108283978