MicroRNA and Other Non-Coding RNAs in Epstein-Barr Virus-Associated Cancers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F21%3A73610370" target="_blank" >RIV/61989592:15110/21:73610370 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2072-6694/13/15/3909" target="_blank" >https://www.mdpi.com/2072-6694/13/15/3909</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cancers13153909" target="_blank" >10.3390/cancers13153909</a>

Result language

angličtina

Original language name

MicroRNA and Other Non-Coding RNAs in Epstein-Barr Virus-Associated Cancers

Original language description

Simple Summary Epstein-Barr virus (EBV) is associated with a variety of malignancies. In this review, we discuss EBV-encoded microRNAs and ncRNAs and consider how their detection could aid in the diagnosis, prognostication, and monitoring of treatment in patients with EBV-associated malignancies, including classical Hodgkin&apos;s lymphoma (cHL), Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL), nasopharyngeal carcinoma (NPC), and gastric carcinoma (GC). EBV is a direct causative agent in around 1.5% of all cancers. The oncogenic properties of EBV are related to its ability to activate processes needed for cellular proliferation, survival, migration, and immune evasion. The EBV latency program is required for the immortalization of infected B cells and involves the expression of non-coding RNAs (ncRNAs), including viral microRNAs. These ncRNAs have different functions that contribute to virus persistence in the asymptomatic host and to the development of EBV-associated cancers. In this review, we discuss the function and potential clinical utility of EBV microRNAs and other ncRNAs in EBV-associated malignancies. This review is not intended to be comprehensive, but rather to provide examples of the importance of ncRNAs.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molecular, cellular and clinical approach to healthy ageing</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancers

ISSN

2072-6694

e-ISSN

—

Volume of the periodical

13

Issue of the periodical within the volume

15

Country of publishing house

CH - SWITZERLAND

Number of pages

26

Pages from-to

"nestránkováno"

UT code for WoS article

000681933800001

EID of the result in the Scopus database

2-s2.0-85111638216