Specialized pro-resolving lipid mediators: The future of chronic pain therapy?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F21%3A73610538" target="_blank" >RIV/61989592:15110/21:73610538 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1422-0067/22/19/10370" target="_blank" >https://www.mdpi.com/1422-0067/22/19/10370</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms221910370" target="_blank" >10.3390/ijms221910370</a>
Alternative languages
Result language
angličtina
Original language name
Specialized pro-resolving lipid mediators: The future of chronic pain therapy?
Original language description
Chronic pain (CP) is a severe clinical entity with devastating physical and emotional consequences for patients, which can occur in a myriad of diseases. Often, conventional treatment approaches appear to be insufficient for its management. Moreover, considering the adverse effects of traditional analgesic treatments, specialized pro-resolving lipid mediators (SPMs) have emerged as a promising alternative for CP. These include various bioactive molecules such as resolvins, maresins, and protectins, derived from omega-3 polyunsaturated fatty acids (PUFAs); and lipoxins, produced from omega-6 PUFAs. Indeed, SPMs have been demonstrated to play a central role in the regulation and resolution of the inflammation associated with CP. Furthermore, these molecules can modulate neuroinflammation and thus inhibit central and peripheral sensitizations, as well as long-term potentiation, via immunomodulation and regulation of nociceptor activity and neuronal pathways. In this context, preclinical and clinical studies have evidenced that the use of SPMs is beneficial in CP-related disorders, including rheumatic diseases, migraine, neuropathies, and others. This review integrates current preclinical and clinical knowledge on the role of SPMs as a potential therapeutic tool for the management of patients with CP.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1661-6596
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
19
Country of publishing house
CH - SWITZERLAND
Number of pages
18
Pages from-to
"nestránkováno"
UT code for WoS article
000709785500001
EID of the result in the Scopus database
2-s2.0-85115787392