Butyrate, a typical product of gut microbiome, affects function of the AhR gene, being a possible agent of crosstalk between gut microbiome, and hepatic drug metabolism
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F22%3A73614961" target="_blank" >RIV/61989592:15110/22:73614961 - isvavai.cz</a>
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S0955286322001139?token=043F05965D78FC9DE8B7DB5874F2BB4D07D70C131CFA168C2667A0E2CDCA059830AD72751A4D157537D479FF50BA7331&originRegion=eu-west-1&originCreation=20221220185342" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0955286322001139?token=043F05965D78FC9DE8B7DB5874F2BB4D07D70C131CFA168C2667A0E2CDCA059830AD72751A4D157537D479FF50BA7331&originRegion=eu-west-1&originCreation=20221220185342</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jnutbio.2022.109042" target="_blank" >10.1016/j.jnutbio.2022.109042</a>
Alternative languages
Result language
angličtina
Original language name
Butyrate, a typical product of gut microbiome, affects function of the AhR gene, being a possible agent of crosstalk between gut microbiome, and hepatic drug metabolism
Original language description
Modulation of gut microbiome composition seems to be a promising therapeutic strategy for a wide range of pathologic states. However, these microbiota-targeted interventions may affect production of microbial metabolites, circulating factors in the gut-liver axis influencing hepatic drug metabolism with possible clinical relevance. Butyrate, a short-chain fatty acid produced through microbial fermentation of dietary fibers in the colon, has well established anti-inflammatory role in the intestine, while the effect of butyrate on the liver is unknown. In this study, we have evaluated the effect of butyrate on hepatic AhR activity and AhR-regulated gene expression. We have showed that AhR and its target genes were upregulated by butyrate in dose-dependent manner in HepG2-C3 as well as in primary human hepatocytes. The involvement of AhR has been proved using specific AhR antagonists and siRNA-mediated AhR silencing. Experiments with AhR reporter cells have shown that butyrate regulates the expression of AhR target genes by modulating the AhR activity. Our results suggest also epigenetic action by butyrate on AhR and its repressor (AHRR) presumably through mechanisms based on HDAC inhibition in the liver. Our results demonstrate that butyrate may influence the drug-metabolizing ability of liver enzymes e.g., through the interaction with AhR-dependent pathways.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
ISSN
0955-2863
e-ISSN
1873-4847
Volume of the periodical
107
Issue of the periodical within the volume
Sep
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
"109042(1)"-"109042(10)"
UT code for WoS article
000806731000002
EID of the result in the Scopus database
2-s2.0-85130826255