Developmental changes in iron metabolism and erythropoiesis in mice with human erythropoietin receptor

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F22%3A73615583" target="_blank" >RIV/61989592:15110/22:73615583 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/ajh.26658" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/ajh.26658</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ajh.26658" target="_blank" >10.1002/ajh.26658</a>

Result language
angličtina
Original language name
Developmental changes in iron metabolism and erythropoiesis in mice with human erythropoietin receptor
Original language description
We previously created a mouse model of PFCP bearing the gain-of-function erythrocytosis-causing human EPOR gene mutation (mtHEPOR) and shown that mtHEPOR embryos develop erythrocytosis around embryonic day (ED)17.5, followed by transient amelioration of erythrocytosis in perinatal life and its reappearance at 3–6 weeks of age. Similarly, erythrocytosis is absent in patients with PFCP in the perinatal period and develops within a few weeks of neonatal life. The mtHEPOR homozygous mice have even greater erythrocytosis than their heterozygous counterparts. Now we investigated how the developmental and age-related changes of erythron in mtHEPOR heterozygotes and homozygotes are interconnected with changes in iron homeostasis.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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