Lack of association between cortical amyloid deposition and glucose metabolism in early stage Alzheimer ́s disease patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F22%3A73615824" target="_blank" >RIV/61989592:15110/22:73615824 - isvavai.cz</a>

Result on the web

<a href="https://sciendo.com/article/10.2478/raon-2021-0051" target="_blank" >https://sciendo.com/article/10.2478/raon-2021-0051</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/raon-2021-0051" target="_blank" >10.2478/raon-2021-0051</a>

Result language

angličtina

Original language name

Lack of association between cortical amyloid deposition and glucose metabolism in early stage Alzheimer ́s disease patients

Original language description

Background. Beta amyloid (Aβ) causes synaptic dysfunction leading to neuronal death. It is still controversial if the magnitude of Aβ deposition correlates with the degree of cognitive impairment. Diagnostic imaging may lead to a better understanding the role of Aβ in development of cognitive deficits. The aim of the present study was to investi-gate if Aβ deposition in the corresponding brain region of early stage Alzheimer ́s disease (AD) patients, directly cor-relates to neuronal dysfunction and cognitive impairment indicated by reduced glucose metabolism.Patients and methods. In 30 patients with a clinical phenotype of AD and amyloid positive brain imaging, 2-[18F] fluoro-2-deoxy-d-glucose (FDG) PET/CT was performed. We extracted the average [18F] flutemetamol (Vizamyl) up-take for each of the 16 regions of interest in both hemispheres and computed the standardized uptake value ratio (SUVR) by dividing the Vimazyl intensities by the mean signal of positive and negative control regions. Data were analysed using the R environment for statistical computing and graphics.Results. Any negative correlation between Aβ deposition and glucose metabolism in 32 dementia related and cor-responding brain regions in AD patients was not found. None of the correlation coefficient values were statistically significant different from zero based on two-sided p- value.Conclusions. Regional Aβ deposition did not correlate negatively with local glucose metabolism in early stage AD patients. Our findings support the role of Aβ as a valid biomarker, but does not permit to conclude that Aβ is a direct cause for an aberrant brain glucose metabolism and neuronal dysfunction.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Radiology and Oncology

ISSN

1318-2099

e-ISSN

1581-3207

Volume of the periodical

56

Issue of the periodical within the volume

1

Country of publishing house

SI - SLOVENIA

Number of pages

31

Pages from-to

23

UT code for WoS article

000734379500001

EID of the result in the Scopus database

2-s2.0-85122013973