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Molecular Mechanisms of Chloroquine and Hydroxychloroquine Used in Cancer Therapy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F23%3A73618913" target="_blank" >RIV/61989592:15110/23:73618913 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.eurekaselect.com/article/123757" target="_blank" >https://www.eurekaselect.com/article/123757</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2174/1871520622666220519102948" target="_blank" >10.2174/1871520622666220519102948</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Molecular Mechanisms of Chloroquine and Hydroxychloroquine Used in Cancer Therapy

  • Original language description

    Tumour relapse, chemotherapy resistance, and metastasis continue to be unsolved issues in cancer therapy. A recent approach has been to scrutinise drugs used in the clinic for other illnesses and modify their structure to increase selectivity to cancer cells. Chloroquine (CQ) and hydroxychloroquine (HCQ), known antimalarials, have successfully treated autoimmune and neoplastic diseases. CQ and HCQ, well-known lysosomotropic agents, induce apoptosis, downregulate autophagy, and modify the tumour microenvironment. Moreover, they affect the Toll 9/NF-κB receptor pathway, activate stress response pathways, enhance p53 activity and CXCR4-CXCL12 expression in cancer cells, which would help explain their effects in cancer treatment. These compounds can normalise the tumour associated vasculature, promote the activation of the immune system, change the phenotype of tumour-associated macrophages (from M2 to M1), and stimulate cancer-associated fibroblasts. We aim to review the historical aspects of CQ and its derivatives and the most relevant mechanisms that support the therapeutic use of CQ and HCQ for the treatment of cancer.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    <a href="/en/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molecular, cellular and clinical approach to healthy ageing</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Anti-Cancer Agents in Medicinal Chemistry

  • ISSN

    1871-5206

  • e-ISSN

    1875-5992

  • Volume of the periodical

    23

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    AE - UNITED ARAB EMIRATES

  • Number of pages

    23

  • Pages from-to

    1122-1144

  • UT code for WoS article

    001025442300003

  • EID of the result in the Scopus database

    2-s2.0-85161055349