SARS-CoV-2 Infection in Venezuelan Pediatric Patients-A Single Center Prospective Observational Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F23%3A73619652" target="_blank" >RIV/61989592:15110/23:73619652 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15640/23:73619652

Result on the web

<a href="https://www.mdpi.com/2227-9059/11/5/1409" target="_blank" >https://www.mdpi.com/2227-9059/11/5/1409</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/biomedicines11051409" target="_blank" >10.3390/biomedicines11051409</a>

Result language

angličtina

Original language name

SARS-CoV-2 Infection in Venezuelan Pediatric Patients-A Single Center Prospective Observational Study

Original language description

Several studies suggest that children infected with SARS-CoV-2 have fewer clinical manifestations than adults; when they develop symptoms, they rarely progress to severe disease. Different immunological theories have been proposed to explain this phenomenon. In September 2020, 16% of the active COVID-19 cases in Venezuela were children under 19 years. We conducted a cross-sectional study of pediatric patients&apos; immune response and clinical conditions with SARS-CoV-2 infection. The patients were admitted to the COVID-19 area of the emergency department of Dr Jose Manuel de los Rios Children&apos;s Hospital (2021-2022). The lymphocyte subpopulations were analyzed by flow cytometry, and IFN?, IL-6, and IL-10 serum concentrations were quantified using commercial ELISA assays. The analysis was conducted on 72 patients aged one month to 18 years. The majority, 52.8%, had mild disease, and 30.6% of the patients were diagnosed with MIS-C. The main symptoms reported were fever, cough, and diarrhea. A correlation was found between IL-10 and IL-6 concentrations and age group, lymphocyte subpopulations and nutritional status and steroid use, and IL-6 concentrations and clinical severity. The results suggest a different immune response depending on age and nutritional status that should be considered for treating pediatric COVID-19 patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedicines

ISSN

2227-9059

e-ISSN

—

Volume of the periodical

11

Issue of the periodical within the volume

5

Country of publishing house

CH - SWITZERLAND

Number of pages

15

Pages from-to

1409

UT code for WoS article

001011342200001

EID of the result in the Scopus database

2-s2.0-85160809729