Increased blood reactive oxygen species and hepcidin in obstructive sleep apnea precludes expected erythrocytosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F23%3A73619895" target="_blank" >RIV/61989592:15110/23:73619895 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/23:10158062
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/ajh.26992" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/ajh.26992</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ajh.26992" target="_blank" >10.1002/ajh.26992</a>
Alternative languages
Result language
angličtina
Original language name
Increased blood reactive oxygen species and hepcidin in obstructive sleep apnea precludes expected erythrocytosis
Original language description
Obstructive sleep apnea (OSA) causes intermittent hypoxia during sleep. Hypoxia predictably initiates an increase in the blood hemoglobin concentration (Hb); yet in our analysis of 527 patients with OSA, >98% did not have an elevated Hb. To understand why patients with OSA do not develop secondary erythrocytosis due to intermittent hypoxia, we first hypothesized that erythrocytosis occurs in these patients, but is masked by a concomitant increase in plasma volume. However, we excluded that explanation by finding that the red cell mass was normal (measured by radionuclide labeling of erythrocytes and carbon monoxide inhalation). We next studied 45 patients with OSA before and after applying continuous positive airway pressure (CPAP). We found accelerated erythropoiesis in these patients (increased erythropoietin and reticulocytosis), but it was offset by neocytolysis (lysis of erythrocytes newly generated in hypoxia upon return to normoxia). Parameters of neocytolysis included increased reactive oxygen species from expanded reticulocytes' mitochondria. The antioxidant catalase was also downregulated in these cells from hypoxia-stimulated microRNA-21. In addition, inflammation-induced hepcidin limited iron availability for erythropoiesis. After CPAP, some of these intermediaries diminished but Hb did not change. We conclude that in OSA, the absence of significant increase in red cell mass is integral to the pathogenesis, and results from hemolysis via neocytolysis combined with inflammation-mediated suppression of erythropoiesis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
AMERICAN JOURNAL OF HEMATOLOGY
ISSN
0361-8609
e-ISSN
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Volume of the periodical
98
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
1265-1276
UT code for WoS article
001019254300001
EID of the result in the Scopus database
2-s2.0-85162895114