3D-Printed Polycaprolactone Implants Modified with Bioglass and Zn-Doped Bioglass

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F23%3A73620861" target="_blank" >RIV/61989592:15110/23:73620861 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/1996-1944/16/3/1061" target="_blank" >https://www.mdpi.com/1996-1944/16/3/1061</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ma16031061" target="_blank" >10.3390/ma16031061</a>

Result language

angličtina

Original language name

3D-Printed Polycaprolactone Implants Modified with Bioglass and Zn-Doped Bioglass

Original language description

In this work, composite filaments in the form of sticks and 3D-printed scaffolds were investigated as a future component of an osteochondral implant. The first part of the work focused on the development of a filament modified with bioglass (BG) and Zn-doped BG obtained by injection molding. The main outcome was the manufacture of bioactive, strong, and flexible filament sticks of the required length, diameter, and properties. Then, sticks were used for scaffold production. We investigated the effect of bioglass addition on the samples mechanical and biological properties. The samples were analyzed by scanning electron microscopy, optical microscopy, infrared spectroscopy, and microtomography. The effect of bioglass addition on changes in the SBF mineralization process and cell morphology was evaluated. The presence of a spatial microstructure within the scaffolds affects their mechanical properties by reducing them. The tensile strength of the scaffolds compared to filaments was lower by 58-61%. In vitro mineralization experiments showed that apatite formed on scaffolds modified with BG after 7 days of immersion in SBF. Scaffold with Zn-doped BG showed a retarded apatite formation. Innovative 3D-printing filaments containing bioglasses have been successfully applied to print bioactive scaffolds with the surface suitable for cell attachment and proliferation.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/GF21-45449L" target="_blank" >GF21-45449L: 3D and 4D printing of stimuli-responsive and functionally graded biomaterials for osteochondral defects regeneration</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Materials

ISSN

1996-1944

e-ISSN

—

Volume of the periodical

16

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

16

Pages from-to

1061

UT code for WoS article

000929713400001

EID of the result in the Scopus database

2-s2.0-85147954231