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Myositis Autoantibodies in Patients with Suspected Post-Treatment Lyme Disease Syndrome

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F23%3A73621444" target="_blank" >RIV/61989592:15110/23:73621444 - isvavai.cz</a>

  • Alternative codes found

    RIV/00098892:_____/23:10157904

  • Result on the web

    <a href="https://www.mdpi.com/2075-1729/13/2/527" target="_blank" >https://www.mdpi.com/2075-1729/13/2/527</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/life13020527" target="_blank" >10.3390/life13020527</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Myositis Autoantibodies in Patients with Suspected Post-Treatment Lyme Disease Syndrome

  • Original language description

    Most patients suffering from Lyme disease are effectively treated with antibiotics. Insome patients, however, problems persist for a long time despite appropriate therapy. The termpost-treatment Lyme disease syndrome (PTLDS) is currently used for this condition in scientificliterature. The pathogenesis is still not precisely known, but the involvement of immunopathologicalmechanisms is assumed. In our study, we analyzed the presence of autoantibodies including myositisspecific(MSA) and myositis-associated autoantibodies (MAA) in patients with laboratory provenhistory of Lyme disease and with clinical symptoms of PTLDS. A total of 59 patients meeting thecriteria for PTLDS were enrolled in this study. The control group consisted of 40 patients undergoingdifferential diagnosis of neurological disorders without clinical and/or laboratory-proven history ofLyme disease. The presence of autoantibodies was determined by immunoblot methods and positivesamples were further tested for serum creatine kinase (CK) and myoglobin levels. The presence ofmyositis autoantibodies was detected in 18 subjects with suspected PTLDS (30.5%), but only in 5%of control subjects exhibiting no evidence of Lyme disease history. The difference was statisticallysignificant (p = 0.002). The subsequent biochemical analysis of muscle-damage markers in positivesubjects found a mild elevation in six MSA/MAA-positive PTLDS patients. The study detected raisedMSA/MAA autoantibodies formation in the group of PTLDS patients raising the question abouttheir involvement in the pathogenesis of this syndrome.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30102 - Immunology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Life

  • ISSN

    2075-1729

  • e-ISSN

    2075-1729

  • Volume of the periodical

    13

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    8

  • Pages from-to

    527

  • UT code for WoS article

    000940123400001

  • EID of the result in the Scopus database

    2-s2.0-85148956065