Near-infrared pH-switchable BODIPY photosensitizers for dual biotin/ cRGD targeted photodynamic therapy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F24%3A73626452" target="_blank" >RIV/61989592:15110/24:73626452 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/24:73626452
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1011134424001702" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1011134424001702</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jphotobiol.2024.113010" target="_blank" >10.1016/j.jphotobiol.2024.113010</a>

Result language
angličtina
Original language name
Near-infrared pH-switchable BODIPY photosensitizers for dual biotin/ cRGD targeted photodynamic therapy
Original language description
Photodynamic therapy (PDT) is a clinically-approved cancer treatment that is based on production of cytotoxic reactive oxygen species to induce cell death. However, its efficiency depends on distribution of photosensitizer (PS) and depth of light penetration through the tissues. Tendency of pathological cancer tissues to exhibit lower pH than healthy tissues inspired us to explore dual-targeted pH-activatable photosensitizers based on tunable near-infrared (NIR) boron-dipyrromethene (BODIPY) dyes. Our BODIPY PSs were designed to carry three main attributes: (i) biotin or cRGD peptide as an effective cancer cell targeting unit, (ii) amino moiety that is protonated in acidic (pH 640nm) allowed for high phototoxicity against HeLa (alpha(v)beta(3) integrin and biotin receptor positive) and A549 (biotin receptor positive) cells compared to healthy MRC-5 (biotin negative) cells. Moreover, no dark toxicity was observed on selected cell lines (>10 mu M) providing promising photosensitizers for tumour-targeted photodynamic therapy.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Project
<a href="/en/project/LX22NPO5102" target="_blank" >LX22NPO5102: National institute for cancer research</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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