Delivery of N-heterocyclic drugs, acids, phenols, and thiols via Tailor−made Self−immolative linkers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F24%3A73630049" target="_blank" >RIV/61989592:15110/24:73630049 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S2772417424000888" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2772417424000888</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejmcr.2024.100216" target="_blank" >10.1016/j.ejmcr.2024.100216</a>
Alternative languages
Result language
angličtina
Original language name
Delivery of N-heterocyclic drugs, acids, phenols, and thiols via Tailor−made Self−immolative linkers
Original language description
Heterocyclic drugs display diverse pharmacological activities and metabolic stability. However, their poor solubility and pharmacokinetic properties often compromise bioavailability and clinical outcomes. Nevertheless, the prodrug approach provides a viable strategy to overcome unwanted attributes of drug candidates. In this proof-of-concept study, we report the synthesis and biological evaluation of glycol methylene-bridged phosphate (GMBP) prodrugs developed for heterocyclic drug delivery. Through methylene bridging, the heterocyclic nitrogen was directly attached to the phosphate, whereas the glycol moiety enabled drug release via cyclization, as confirmed by 31P NMR spectroscopy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10609 - Biochemical research methods
Result continuities
Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF MOLECULAR STRUCTURE
ISSN
0022-2860
e-ISSN
1872-8014
Volume of the periodical
12
Issue of the periodical within the volume
December 2024
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
29
Pages from-to
100216
UT code for WoS article
001333935900001
EID of the result in the Scopus database
2-s2.0-85205486834