Diffusion-weighted imaging and retinal oximetry as potential biomarkers of visual outcomes after optic neuritis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F25%3A73632056" target="_blank" >RIV/61989592:15110/25:73632056 - isvavai.cz</a>
Alternative codes found
RIV/61383082:_____/25:00001548 RIV/00216224:14740/25:00142274 RIV/00098892:_____/25:10159477
Result on the web
<a href="https://www.nature.com/articles/s41598-025-19331-w" target="_blank" >https://www.nature.com/articles/s41598-025-19331-w</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-025-19331-w" target="_blank" >10.1038/s41598-025-19331-w</a>
Alternative languages
Result language
angličtina
Original language name
Diffusion-weighted imaging and retinal oximetry as potential biomarkers of visual outcomes after optic neuritis
Original language description
To elucidate the mechanisms influencing visual function recovery after optic neuritis (ON), this study employed a multicompartment diffusion weighted imaging (DWI) model to assess the role of optic radiation integrity and its relationship with retinal parameters, including automatic retinal oximetry and retinal nerve fiber layer (RNFL) thinning. Twenty-four patients with the first episode of acute unilateral ON were compared with 56 healthy volunteers with normal vision. Additionally, longitudinal analysis 3 and 6 months after ON was performed in 17 patients. Multivariate analysis of variance across baseline DWI metrics revealed a greater secondary partial volume fraction (f2) in patients. In the longitudinal analysis, a multivariate effect of time was observed only when adjusted for the affected side and time since onset; however, univariate post hoc tests were nonsignificant. An unadjusted model stratified according to clinical outcomes (best-corrected visual acuity [BCVA] and contrast sensitivity) indicated lower overall fractional anisotropy (FA) in patients with incomplete recovery. In the correlation analysis, baseline FA and oximetry (venous saturation and arteriovenous difference) predicted follow-up BCVA, whereas axial diffusivity predicted follow-up oximetry. In turn, baseline oximetry predicted follow-up RNFL thickness. In summary, DWI and retinal oximetry are both potential predictors of visual function outcomes after ON.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
<a href="/en/project/NV19-06-00216" target="_blank" >NV19-06-00216: Morphological and pathophysiological changes of the retina and visual pathway in optic neuritis associated with multiple sclerosis</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
2045-2322
Volume of the periodical
15
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
15
Pages from-to
"Article Number:35445"
UT code for WoS article
001591900900036
EID of the result in the Scopus database
2-s2.0-105018398817