Multi-hit TP53 confers the poorest survival in multiple myeloma in the era of novel therapies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F25%3A73634064" target="_blank" >RIV/61989592:15110/25:73634064 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1186/s10020-025-01392-2" target="_blank" >https://link.springer.com/article/10.1186/s10020-025-01392-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s10020-025-01392-2" target="_blank" >10.1186/s10020-025-01392-2</a>
Alternative languages
Result language
angličtina
Original language name
Multi-hit TP53 confers the poorest survival in multiple myeloma in the era of novel therapies
Original language description
This study investigates the prognostic impact of multi-hit TP53 in patients with multiple myeloma treated in the era of novel therapeutic agents. Multi-hit TP53, defined as the presence of del(17p) combined with a TP53 mutation or at least two TP53 mutations, was analyzed in a real-world cohort of 204 patients. The results demonstrate that patients harboring multi-hit TP53 exhibit the poorest progression-free survival and overall survival compared with other high-risk cytogenetic groups and standard-risk patients. Multi-hit TP53 was associated with advanced disease stage and treatment resistance, highlighting its role as a critical adverse prognostic factor. These findings support the routine assessment of TP53 abnormalities for improved risk stratification and therapeutic decision-making in multiple myeloma.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
MOLECULAR MEDICINE
ISSN
1076-1551
e-ISSN
1528-3658
Volume of the periodical
32
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
3
UT code for WoS article
001654157200001
EID of the result in the Scopus database
2-s2.0-105026628843