Protective factors against oxidative stress in COPD: focus on Nrf2-dependent antioxidant gene expression

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F25%3A73634128" target="_blank" >RIV/61989592:15110/25:73634128 - isvavai.cz</a>

Result on the web

<a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1492256/full" target="_blank" >https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1492256/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fmed.2025.1492256" target="_blank" >10.3389/fmed.2025.1492256</a>

Result language

angličtina

Original language name

Protective factors against oxidative stress in COPD: focus on Nrf2-dependent antioxidant gene expression

Original language description

Chronic obstructive pulmonary disease (COPD) continues to be the world&apos;s primary cause of morbidity and mortality. The main mechanism driving the pathogenesis of COPD is oxidative stress. Antioxidant genes, regulated by the Nrf2/ARE signaling pathway, play a protective role against oxidative stress. Unfortunately, this pathway appears to be dysregulated in COPD, leading to decreased expression of antioxidant genes and persistent oxidative stress. We reviewed numerous studies measuring the expression of antioxidant genes in COPD. We also focused on developments in methods used to study gene expression in COPD over time, along with measuring antioxidant gene expression in various cell types, and the potential use of antioxidant gene expression as a predictor of COPD progression. And last but not least we discussed the association of cigarette smoke exposure with antioxidant gene expression together with antioxidant treatment in COPD. Understanding the altered expression of antioxidant genes in COPD could help in treating COPD, as well as predicting its progression.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30218 - General and internal medicine

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Medicine

ISSN

2296-858X

e-ISSN

2296-858X

Volume of the periodical

12

Issue of the periodical within the volume

May

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

1492256

UT code for WoS article

001488471500001

EID of the result in the Scopus database

2-s2.0-105005269211