Current status of adjuvant immunotherapy and relapse management in renal cell carcinoma: Insights from a European delphi study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F25%3A73635355" target="_blank" >RIV/61989592:15110/25:73635355 - isvavai.cz</a>
Result on the web
<a href="https://www.ejcancer.com/article/S0959-8049(25)00351-X/fulltext" target="_blank" >https://www.ejcancer.com/article/S0959-8049(25)00351-X/fulltext</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejca.2025.115569" target="_blank" >10.1016/j.ejca.2025.115569</a>
Alternative languages
Result language
angličtina
Original language name
Current status of adjuvant immunotherapy and relapse management in renal cell carcinoma: Insights from a European delphi study
Original language description
Introduction: Adjuvant immunotherapy has remarkably advanced the management of localized renal cell carcinoma (RCC) in patients at high risk of post-surgery recurrence. This Delphi study aimed to establish expert consensus on its use and subsequent management of relapse. Methods: Fifteen RCC experts participated in a two-round Delphi process between July and November 2024. The study included 43 core survey items, divided into 67 components for comprehensive evaluation. Results: Consensus, defined as ≥ 75 % agreement, was achieved for 39 of 67 items (58.2 %). Experts agreed on using the Leibovich score for selecting patients for adjuvant pembrolizumab (79 %), initiating therapy within 90 days post-surgery (86 %), and not restricting treatment to programmed death ligand-1 (PD-L1)-positive tumors (100 %). Plasma kidney injury molecule-1 (KIM-1) was considered by the experts as a potential useful recurrence risk biomarker (93 %). Immune checkpoint inhibitor (ICI)-refractory disease was defined as relapse within 6 months post-adjuvant therapy (80 %). Focal therapies for oligometastatic recurrence (80 %), and targeted therapies or clinical trial enrollment for ICI-refractory patients (87 %) were supported. Belzutifan was recommended for fourth-line or later use after ICI therapy and multiple tyrosine kinase inhibitors (93 %). By contrast, no consensus was reached on ICI salvage therapy in specific subgroups, including patients with clear-cell RCC (60 %), without bone/brain metastases (60 %), good performance status (60 %), low tumor burden (47 %), or papillary RCC (36 %). Conclusions: This Delphi study provides insights into the evolving role of adjuvant immunotherapy in localized RCC and relapse management. A multidisciplinary approach and periodic review are essential to optimizing treatment strategies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
EUROPEAN JOURNAL OF CANCER
ISSN
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e-ISSN
1879-0852
Volume of the periodical
225
Issue of the periodical within the volume
July
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
115569
UT code for WoS article
001511440900001
EID of the result in the Scopus database
2-s2.0-105007827388