Multi-Omics Analysis Reveals a HIF Network and Hub Gene EPAS1 Associated with Lung Adenocarcinoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15120%2F18%3A73589775" target="_blank" >RIV/61989592:15120/18:73589775 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/18:A20020PR
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S2352396418301889?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2352396418301889?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ebiom.2018.05.024" target="_blank" >10.1016/j.ebiom.2018.05.024</a>
Alternative languages
Result language
angličtina
Original language name
Multi-Omics Analysis Reveals a HIF Network and Hub Gene EPAS1 Associated with Lung Adenocarcinoma
Original language description
Recent technological advancements have permitted high-throughput measurement of the human genome, epigenome, metabolome, transcriptome, and proteome at the population level. We hypothesized that subsets of genes identified from omic studies might have closely related biological functions and thus might interact directly at the network level. Therefore, we conducted an integrative analysis of multi-omic datasets of nonsmall cell lung cancer (NSCLC) to search for association patterns beyond the genome and transcriptome. A large, complex, and robust gene network containing well-known lung cancer-related genes, including EGFR and TERT, was identified from combined gene lists for lung adenocarcinoma. Members of the hypoxia-inducible factor (HIF) gene familywere at the center of this network. Subsequent sequencing of network hub geneswithin a subset of samples fromthe Transdisciplinary Research in Cancer of the Lung-International Lung Cancer Consortium (TRICL-ILCCO) consortium revealed a SNP (rs12614710) in EPAS1 associated with NSCLC that reached genome-wide significance (OR = 1.50; 95% CI: 1.31-1.72; p = 7.75 x 10(-9)). Using imputed data, we found that this SNP remained significant in the entire TRICL-ILCCO consortium (p =.03). Additional functional studies are warranted to better understand interrelationships among genetic polymorphisms, DNA methylation status, and EPAS1 expression.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30401 - Health-related biotechnology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
EBioMedicine
ISSN
2352-3964
e-ISSN
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Volume of the periodical
2018
Issue of the periodical within the volume
32
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
9
Pages from-to
93-101
UT code for WoS article
000436312000014
EID of the result in the Scopus database
2-s2.0-85047757715