Diesel Engine Exhaust Exposure, Smoking, and Lung Cancer Subtype Risks A Pooled Exposure-Response Analysis of 14 Case-Control Studies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15120%2F20%3A73602430" target="_blank" >RIV/61989592:15120/20:73602430 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/20:10413834 RIV/00209805:_____/20:00078387

Result on the web

<a href="https://www.atsjournals.org/doi/full/10.1164/rccm.201911-2101OC" target="_blank" >https://www.atsjournals.org/doi/full/10.1164/rccm.201911-2101OC</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1164/rccm.201911-21010C" target="_blank" >10.1164/rccm.201911-21010C</a>

Result language

angličtina

Original language name

Diesel Engine Exhaust Exposure, Smoking, and Lung Cancer Subtype Risks A Pooled Exposure-Response Analysis of 14 Case-Control Studies

Original language description

Rationale: Although the carcinogenicity of diesel engine exhaust has been demonstrated in multiple studies, little is known regarding exposure-response relationships associated with different exposure subgroups and different lung cancer subtypes. Objectives: We expanded on a previous pooled case-control analysis on diesel engine exhaust and lung cancer by including three additional studies and quantitative exposure assessment to evaluate lung cancer and subtype risks associated with occupational exposure to diesel exhaust characterized by elemental carbon (EC) concentrations. Methods: We used a quantitative EC job-exposure matrix for exposure assessment. Unconditional logistic regression models were used to calculate lung cancer odds ratios and 95% confidence intervals (CIs) associated with various metrics of EC exposure. Lung cancer excess lifetime risks (ELR) were calculated using life tables accounting for all-cause mortality. Additional stratified analyses by smoking history and lung cancer subtypes were performed in men. Measurements and Main Results: Our study included 16,901 lung cancer cases and 20,965 control subjects. In men, exposure response between EC and lung cancer was observed: odds ratios ranged from 1.09 (95% CI, 1.00-1.18) to 1.41 (95% CI, 1.30-1.52) for the lowest and highest cumulative exposure groups, respectively. EC-exposed men had elevated risks in all lung cancer subtypes investigated; associations were strongest for squamous and small cell carcinomas and weaker for adenocarcinoma. EC lung cancer exposure response was observed in men regardless of smoking history, including in never-smokers. ELR associated with 45 years of EC exposure at 50, 20, and 1 mu g/m(3) were 3.0%, 0.99%, and 0.04%, respectively, for both sexes combined. Conclusions: We observed a consistent exposure-response relationship betweenECexposure and lung cancer in men. Reduction of workplace EC levels to background environmental levels will further reduce lung cancer ELR in exposed workers.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30302 - Epidemiology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

ISSN

1073-449X

e-ISSN

—

Volume of the periodical

202

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

402-411

UT code for WoS article

000558635400020

EID of the result in the Scopus database

2-s2.0-85089127431