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Epidemiological study on more accurate diagnosis of prostate cancer

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15120%2F20%3A73603391" target="_blank" >RIV/61989592:15120/20:73603391 - isvavai.cz</a>

  • Result on the web

    <a href="http://cejph.szu.cz/artkey/cjp-202001-0011_epidemiological-study-on-more-accurate-diagnosis-of-prostate-cancer.php" target="_blank" >http://cejph.szu.cz/artkey/cjp-202001-0011_epidemiological-study-on-more-accurate-diagnosis-of-prostate-cancer.php</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.21101/cejph.a5720" target="_blank" >10.21101/cejph.a5720</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Epidemiological study on more accurate diagnosis of prostate cancer

  • Original language description

    Objective: The study aimed at assessing the potential benefit of prostate health index (PHI) for early detection of prostate cancer (PCa) and the use of PHI as a marker predicting the presence of PCa before performing prostate biopsy. Methods: The study comprised 55 males who underwent prostate biopsy. Before the procedure, blood samples were collected to test prostate specific antigen (PSA) and free/total PSA ratio (%fPSA) and PHI was calculated. Receiver operating characteristic (ROC) analysis was used to assess the benefit of these values for predicting the presence of PCa. Results: Based on histological examination 31 males were diagnosed with PCa, the remaining 24 were negative. Among the PCa patients, 39% had a Gleason score of 6, 26% had a score of 7 and 35% had a score of 8-10. There were statistically significant differences in PHI and PSA between males with and without PCa. The areas under the ROC curve for %fPSA, total PSA and PHI were 0.712, 0.746 and 0.789, respectively. PHI showed the best predictive ability to estimate biopsy results. If the cut-off criterion PHI &gt; 36.4 (77.42% sensitivity, 66.67% specificity) had been used, 41.7% of males would have avoided unnecessary biopsy. Conclusion: The use of PHI may considerably improve the accuracy of PCa detection in patients with elevated PSA and thus reduce the number of unnecessary biopsies.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30302 - Epidemiology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Central European Journal of Public Health

  • ISSN

    1210-7778

  • e-ISSN

  • Volume of the periodical

    28

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    5

  • Pages from-to

    65-69

  • UT code for WoS article

    000548269300011

  • EID of the result in the Scopus database

    2-s2.0-85082792809