Age and sex differences in the effectiveness of intradialytic resistance training on muscle function

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15260%2F23%3A73622211" target="_blank" >RIV/61989592:15260/23:73622211 - isvavai.cz</a>

Result on the web

<a href="https://www.nature.com/articles/s41598-023-30621-z" target="_blank" >https://www.nature.com/articles/s41598-023-30621-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-023-30621-z" target="_blank" >10.1038/s41598-023-30621-z</a>

Result language

angličtina

Original language name

Age and sex differences in the effectiveness of intradialytic resistance training on muscle function

Original language description

Previous research shows the beneficial effects of an intradialytic resistance training (IRT) on muscle function in haemodialysis patients. However, patients vary highly in their functional responses to IRT, may be due to effects of age and sex heterogeneities in adaptation. Therefore, the aim of this study was to investigate the degree to which the effects of IRT on the muscle function of haemodialysis patients vary by age and sex. We included 57 patients who completed a 12-week IRT (EXG) and 33 patients who received no IRT (CNG) during haemodialysis. Muscle function (MF) was assessed using dynamometry before and after a 12-week intervention and after a 12-week follow-up. After the 12-week intervention, we found a moderation effect of age in the relative (%) change (p = 0.011) and absolute (?) change (p = 0.027) of MF, and a moderation effect of sex in %MF (p = 0.001), but not in ?MF (p = 0.069). Regarding patients&apos; age, the change of MF was only significantly different between EXG and CNG patients aged 60-70 years (%MF, EXG: + 34.6%, CNG: - 20.1%, p &lt; 0.001; ?MF, EXG: + 44.4 N, CNG: - 22.1 N, p &lt; 0.001). Regarding patients&apos; sex, the change of MF was only significantly different between EXG and CNG female patients (%MF, EXG: + 23.9%, CNG: - 23.6%, p &lt; 0.001). Age and sex did not significantly moderate changes in MF measures after 12 weeks of follow-up. We conclude that both age and sex of haemodialysis patients affect their functional response to IRT in the short term.Trial Registration: Intradialytic Resistance Training in Haemodialysis Patients (IRTHEP)-#NCT03511924, 30/04/2018, https://clinicaltrials.gov/ct2/show/NCT03511924 .

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30217 - Urology and nephrology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific Reports

ISSN

2045-2322

e-ISSN

2045-2322

Volume of the periodical

13

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

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UT code for WoS article

000992078000070

EID of the result in the Scopus database

2-s2.0-85149380149