Purine based inhibitors of cyclin-dependent kinases

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F03%3A00001572" target="_blank" >RIV/61989592:15310/03:00001572 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Purine based inhibitors of cyclin-dependent kinases
Original language description
Inhibition of cyclin-dependent kinases (CDK's), the most promising drug target of the new era, became one of the most suitable methods for stopping the division of cancer cells. Several families of low molecular weight compounds were identified as specific CDK inhibitors, sharing a common ATP competing mechanism [1-2]. Some of them have already undergone in vivo efficacy studies, preclinical and clinical evaluation, and thus confirmed the selected CDK's as a proper target for development of new anticancer drugs. Up to now the advancement of purine CDK inhibitors has been based mainly on modifications of substituents at positions 2, 6 and 9, respectively [1-3]. To extend the inhibitor-CDK mutual interactions in a different manner, we introduced anotherside chain at C-8 of purine and rearranged the purine heteroatoms, respectively.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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