Lessons from known P450 structures
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F04%3A00002037" target="_blank" >RIV/61989592:15310/04:00002037 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Lessons from known P450 structures
Original language description
There is a considerable progress last five years in knowledge of the P450 (CYP) structures which allows to draw out at least some conclusions important for function of the respective enzymes. First, the structure of mammalian (rabbit) liver microsomal CYP2C5 was published in 2000 which allowed for detailed comparisons of all important human liver microsomal P450s. The next milestone was the structure of CYP2C9 presented in full in 2003 showing the first human liver microsomal P450 in the absence as wellas in the presence of substrate. Third success was the resolution of the CYP3A4 structure presented this year. The structures show that although the overall "P450 fold" is preserved, there are considerable differences in the ways the substrates approachthe active site and in the properties of the active site itself. Relative flexibility and openness of the CYP3A4 active site was expected by the modeling as well as by the spectroscopic approaches. The CYP2C9 structure opens a possibilit
Czech name
Známé struktury cytochromu P450
Czech description
Článek se zabývá známými strukturami cytochromu P450.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA203%2F99%2F0277" target="_blank" >GA203/99/0277: Cytochrome P450 3A - key enzyme of drug metabolism. Comparison of the human enzyme and of the model system</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Universitatis Palackianae Olomucensis, Facultas Rerum Naturalium, Chemica
ISSN
0232-0061
e-ISSN
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Volume of the periodical
43
Issue of the periodical within the volume
Suppl.
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
275
Pages from-to
198
UT code for WoS article
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EID of the result in the Scopus database
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